Epithelial cell line useful in the detection of dioxinlike compo

Details Epithelial cell line useful in the detection of dioxinlike compo Epithelial cell line useful in the detection of dioxinlike compo

1985-06-14

1990-02-27

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 29, 43524023, 435948, 436 63, 436815, C12N 500, C12Q 102

Patent

active

049045954

ABSTRACT:
This invention relates to a novel epithelial cell line, a process for the preparation of the cell line, and its use in an in vitro bioassay for dioxinlike activity based on alterations in the cell line proliferation and morphology. The proprietary cell line of this invention exhibits a dioxin-induced, reversible, postconfluent inhibition of cell proliferation and a characteristic dioxin-induced flat-cell morphology.

REFERENCES:
patent: 4016036 (1977-04-01), Green et al.
patent: 4569916 (1986-02-01), Penman et al.
Gierthy, J. F. et al., "Reversible Inhibition of In Vitro Epithelial Cell Proliferation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin", Toxicol. Appl. Pharmacol., 74:91-98, 1984.
Knutson, J. C., "Keratinization of Mouse Teratoma Cell Line XB Produced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: an in Vitro Model of Toxicity", Cell 22:27-36, Nov. 1980 (Part 1).
Rheinwald, J. G. et al., "Formation of a Keratinizing Epithelium in Culture by a Cloned Cell Line Derived from a Teratoma", Cell 6:317-330, Nov. 1985.

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