Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1982-02-17
1985-03-26
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
424326, 514674, 514927, A61K 3113, A61K 31155
Patent
active
045073210
ABSTRACT:
Disclosed herein are compositions containing aliphatic di- and polyamine, or agmatine which are useful to regulate, i.e., stimulate or inhibit, epithelial cell growth. The compositions containing low concentrations of these compounds, by virtue of their epithelial cell growth stimulating activity, are useful in promoting wound healing, treating burns, treating ischemic, debubitus and peptic ulcers, plastic and reconstructive surgery, dermatological disorders, promoting autograft and homograft growth, stimulating organ and tissue regeneration in vitro and in vivo, as a component in defined (serum protein-free) media for cultured cells.
Compositions containing these compounds in higher concentrations are useful in the inhibition of cell growth and are useful in the treatment of psoriasis and in retardation of fibrosis after injuries to the spinal cord and nervous system. Also disclosed are various methodologies for utilizing such compositions.
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Index of Tumor Chemotherapy, Dyer, pp. 10-12, 65, 72 and 73, (Mar. 1949).
CA 73: 11798e, Nishiyama, (1961).
CA 94: 206426t, Coffino, (1981).
Abramson Freda L.
Behr Omri M.
Goldberg Jerome D.
The Research Foundation of State University of New York
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