Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1994-05-03
1997-07-01
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530325, 530324, C07K 1400
Patent
active
056440260
ABSTRACT:
The present invention provides a substantially purified polypeptide, epitaxin, which is produced by fibroblasts and can stimulate migration of and DNA synthesis in a tumor cell. The invention also provides antibodies that are specifically reactive with epitaxin and cell lines that produce such antibodies. The invention also provides an active fragment antagonist of ETX activity, which can reduce or inhibit at least one activity of ETX. The invention further provides a method for controlling tumor cell migration and a method for controlling DNA synthesis in a tumor cell, comprising contacting the tumor cell with a composition of the invention. The invention also provides a method of increasing the sensitivity of a tumor cell to a cancer therapeutic agent.
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Shimonaka Motoyuki
Yamaguchi Yu
Gupta Anish
La Jolla Cancer Research Foundation
Tsang Cecilia J.
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