Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1993-12-02
1997-10-07
Chouch, Deborah
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 435 694, 435 695, 435 696, 435 701, 4352401, 4353201, 935 60, C12P 2106, C12P 2102, C12P 2104, C12N 1500
Patent
active
056747039
ABSTRACT:
An episomal vector sytem and methods for use in gene therapy in humans and animals. The vector contains a papilloma virus origin of replication, a vector maintenance sequence, a first promoter transcriptionally linked to a therapeutic nucleic acid sequence, a second promoter transcriptionally linked to a papilloma virus E1 gene sequence, and a third promoter transcriptionally linked to a papilloma virus E2 gene sequence or an E1/E2 fusion gene. The vector is capable of episomal replication in human or animal cells.
REFERENCES:
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Ledley, "Somatic Gene Therapy for Human Disease: Background and Prospects. Part 1", 110(1) J. Pediatrics 1, 1987.
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Sarver et al., "Bovine Papilloma Virus Deoxyribonucleic Acid: A Novel Eucaryotic Cloning Vectro", 1(6) Molec. Cell Biol. 486, 1981.
Spalholz et al., "Transactivation of a Bovine Papilloma Virus Transcriptional Regulatory Element by the E2 Gene Product", 42 Cell 183, 1985.
Ustav et al., "Identification of the Origin of Replication of Bovine Papillomavirus and characterization of the Viral Orgin Recognition Factor E1", 10 (13) EMBO J. 4321, 1991.
Ustav and Stenlund, "Transient Replication of BPV-1 Requires Two viral Polypeptides Encoded by the E1 and E2 Open Reading Frames", 10(2) EMBO J. 449, 1991.
Culver et al., "In vivo Gene Transfer with Retroviral Vectro-Producer Cells for Treatment of Experimental Brain Tumors", 256 Science 1550, 1992.
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Nordloh Peter W.
Stenlund Arne
Woo Savio L. C.
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