Epipodophyllotoxin glucoside lactam derivatives

Details Epipodophyllotoxin glucoside lactam derivatives Epipodophyllotoxin glucoside lactam derivatives

1989-01-30

1990-09-18

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 171, 536 173, 536 174, 536 176, 536 181, 536 182, 514 33, 514 35, C07H 1520, C07H 1700

Patent

active

049580108

ABSTRACT:
Novel antitumor epipodophyllotoxin glucoside lactam derivatives are prepared by first converting the lactone ring of the parent compound to the open-chain trans-hydroxy hydrazide, condensing the hydrazide with a carbonyl compound to form the corresponding hydrazone, and finally cyclizing the trans-hydroxy hydrazone using diethylazodicarboxylate and triphenylphosphine.

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Sinkule et al.; J. Pharm. Sci. 73(2): 164-168 (1984).
Anjanamurthy et al.; Indian J. Chem. 26B:131-135 (1987).

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