Epipodophyllotoxin glucoside 4'-acyl derivatives

Details Epipodophyllotoxin glucoside 4'-acyl derivatives Epipodophyllotoxin glucoside 4'-acyl derivatives

1988-12-02

1990-06-19

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 182, 536 184, 536 172, 536 174, 536 175, 514908, C07H 1526, A61K 3170

Patent

active

049355040

ABSTRACT:
Novel 4'-esters, 4'-carbonates and 4'-carbamates of 4'-demethylepipodophyllotoxin glucosides are disclosed. These agents exhibit antitumor activity in animals.

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patent: 4609644 (1986-09-01), Nemec
patent: 4757138 (1988-07-01), Fujii et al.
McOmie (ED.); Protective Groups in Organic Chemistry; pp. 109-118 (1973).
J. Pharm. Sci., 1983, 72:1158-61.
Anti-Cancer Drug Design, 1987, 2:13-23.

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