Epipodophyllotoxin altroside derivatives

Details Epipodophyllotoxin altroside derivatives Epipodophyllotoxin altroside derivatives

1989-09-01

1991-11-19

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 33, 514 35, 536 41, 536 171, 536 181, 536 172, 536 184, A61K 3170, C07H 1520, C07H 1526

Patent

active

050666452

ABSTRACT:
The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.

REFERENCES:
patent: 3524844 (1970-08-01), Keller-Juslen et al.
patent: 4547567 (1985-10-01), Umezawa et al.
patent: 4564675 (1986-01-01), Kurabayashi et al.
patent: 4716221 (1987-12-01), Umezawa et al.
C. Keller-Juslen, et al., "J. Med. Chem.", 1971 (10) 936-940, Synthesis and Antimitotic Activity of Glycosidic Lignan Derivatives Related to Podophyllotoxin.sup.1.
H. Saito et al., "Chem. Lett.", 1987, 799-802, Syntheses of All Four Possible Diastereomers of Etoposide and Its Aminoglycosidic Analogues via Optical Resolution of (+)-Podophyllotoxin by Glycosidation with D- and L-Sugars.
K. Yamashita, et al., "J. Pharm. Biomed. Anal.", 1987, 5(1):11-20, Measurement of Plasma Etoposide by Radioimmunoassay.

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