Epinephrine as inhibitor of cancerous tumors

Details Epinephrine as inhibitor of cancerous tumors Epinephrine as inhibitor of cancerous tumors

1996-11-18

1999-07-20

Goldberg, Jerome D

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 31135

Patent

active

059256826

ABSTRACT:
A method for reducing cancerous tumors is disclosed. The method includes administering to a mammal an effective amount of epinephrine. In another embodiment, the mammal is immediately immobilized after receiving injections of epinephrine. In a most preferred embodiment, the method also includes administering an effective amount of a cardioselective adrenergic blocking agent prior to administering of epinephrine.

REFERENCES:
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Van Den Brenk, H.A.S., et al., "Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress", Br. J. Cancer, vol. 33, p. 60 (1976).
Ensminger, William D., et al., "Regional chemotherapy of neoplastic diseases", Pharmac. Ther., vol. 21, pp. 277-293 (1983).
Weiner, "Norepinephrine, epinephrine, and the sympathomimetic amines", Goodman and Gibson's the Pharmaceutical Basis of Therapeutics, 8th Edition, Chapter 8, pp. 138-157 (1990).
Hoffmann, B.B., et al., "Adrenergic receptor antagonists", Goodman and Gilson's The Pharmacological Basis of Therapeutics, 8th Edition, Chapter 11, pp. 221-243 (1990).
Ganog, W.F., ed., Review of Medical Physiology, "The adrenal medulla & adrenal cortex", Chapter 20, pp. 323-347 (1993).
Sato, T., et al., Dialog Computerized Abstract of Japanese Journal Article "Itra-arterial chemotherapy with nor-adrenaline experimental study," Gan to Kagaku Ryohu (Japan) 12 (6) pp. 1245-1252 (Jun. 1985).
Dyer, An Index of Tumor Chemotherapy, Wilt, Mar. 1949, pp. 10-12 and 165.
Carter et al, Chemotherapy of Cancer, 2.sup.nd Ed, 1981 John Wiley & Sons, N.Y., N.Y., pp. 362-365.

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