Epimorphin and its encoding nucleic acids

Details Epimorphin and its encoding nucleic acids Epimorphin and its encoding nucleic acids

1996-08-16

1998-03-10

Teng, Sally P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, 435 691, 435 697, C12N 1512, C07K 14435

Patent

active

057262985

ABSTRACT:
Novel physiologically active substance designated as epimorphin which is capable of being expressed by a gene hybridizing with a gene probe composed of the base sequence complementary to part of the base sequence of Sequence ID No. 1 in Sequence Listing, and which is produced by mesenchymal cells derived from human or mouse, and which shows morphogenetic activity of epithelial tissue, and isoforms of said epimorphin, base sequences encoding them, modified epimorphin, in which hydrophobic region at the carboxy terminal of said epimorphin polypeptide has been deleted or replaced by non-hydrophobic polypeptide, and polyclonal antibody or monoclonal antibody produced by the use of a full length or a part of said epimorphin as an antigen are provided. The substances of the present invention can be used for elucidation of the mechanism of diseases caused by abnormal epithelium formation, diagnosis of said diseases, or development of therapeutic methods therefor.

REFERENCES:
Development Growth & Differentiation; Published by The Japanese Society of Developmental Biologists; ISSN 0012-1592; vol. 32, No. 4, pp. 424, 807, Aug. 1990.
Montesano et al., Cell, vol. 69, 697-711, 1991.
Jahoda et al., Nature, vol. 311, 560-562, 1984.
Hirai et al., Cell, vol. 69, p. 471, 1992.
Inoue et al, Biochemical and Biophysical Res. Commun. vol. 187, p. 1144, 1992.
John M. Chirgwin et al "Isolation of Bioligocally Active Ribonucleic Acid From Sources Enriched in Ribonuclease", Biochemistry No. 18, pp. 5294-5299, American Chemical Society, 1979.
T. V. Rhynh et al, DNA Cloning, "Constructing and Screening cDNA Libraries in gt10 and gt11", IRL Press 1984, pp. 48-78.

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