Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates

Details Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates Epiminodeaminodeoxyaminoglycoside antibiotics and intermediates

1975-04-08

1977-04-26

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 12, 536 17, C07H 1522

Patent

active

040202690

ABSTRACT:
Deoxyaminoglycoside antibiotics are prepared in a high yield from phosphorylated aminoglycosides by reacting a phosphorylated aminoglycoside (a) with a silylating agent, or (b) successively with (i) a silylating or acylating agent and (ii) a halogenating agent; then subjecting thus obtained intermediate to reduction. Deoxyaminoglycoside antibiotics are useful for treating infections caused by microorganisms which are resistant or non-resistant to the corresponding aminoglycoside antibiotics.

REFERENCES:
patent: 3753973 (1973-08-01), Umezawa et al.
patent: 3868360 (1975-02-01), Daniels et al.
Umezawa et al., "Jour. of Antibiotics", vol. XXVI, No. 7, 1973, pp. 407-410.
Umezawa et al., "Jour. of Antibiotics", vol. XXVI, No. 12, 1973, pp. 799-800.

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