Epimerization of analogs of vitamin D

Details Epimerization of analogs of vitamin D Epimerization of analogs of vitamin D

2007-04-17

2007-04-17

Qazi, Sabiha N. (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

9,10-seco-cyclopentanohydrophenanthrene ring system or...

C514S167000

Reexamination Certificate

active

10459073

ABSTRACT:
Provided is a method of general applicability of epimerizing a vitamin-D analog having an asymmetric allylic carbon atom at the C-24 position. The method is of particular utility in making calcipotriene.

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Barnett et al., AN 1941:4546 HCAPLUS, DN 35:4546, Sterol group. XLI. A new epimerization process, Journal of the Chemical Society, Abstracts (1940) 1390-3.
Martin J. Calverley, “Synthesis of MC 903, A Biologically Active Vitamin D Metabolite Analogue,” Tetrahedron, vol. 43, No. 20(1987) pp. 4609-4619.

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