Epimerization of 2- or 4- substituted cyclohexanecarboxylic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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562507, 562509, C07B 5500, C07C 6108, C07C 6109

Patent

active

058311181

ABSTRACT:
The present invention relates to a new method for obtaining a purity of about 93% to 100% of the trans form of 2- or 4-substituted cyclohexanecarboxylic acid or reactive derivatives thereof from the cis form or a mixture of the cis and trans forms by a single step, particularly, to a method for obtaining a purity of substantially 100% of the trans form of 4-substituted cyclohexanecarboxylic acid.

REFERENCES:
patent: 4948790 (1990-08-01), Archer et al.
The Merck Index 12th edition, Merck & Co., Inc., Whiehouse Station, NJ, 1996, p. 1315 compound no. 7806.
Cooke, R. G., et al, J. Chem. Soc. 1939, 1245-1247 (1939).
Inukai, T., et al, Chem. Abst. 91:20102s (1979).
Chem. Abst. 95:138635d (1981).
Chem. Abst. 96:51873b (1982).
Chem. Abst. 96:34693a (1982).
Fujimoto, M., Chem. Abst. 105:60344m (1986).

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