Epidioxymanadic acids A and B

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549357, A61K 3135, C07D31902

Patent

active

055147054

ABSTRACT:
The present invention is directed to two novel compounds isolated from a Pacific sponge, Plakortis (Homosclerophorida, Plakinidae) which are designated herein as epidioxymanadic acids A and B. These two compounds have been obtained by a bioassay-guided (i.e., antibiotic activity) isolation procedure, involving solvent partition and chromatography on Sephadex LH-20, cyano, and C-18 columns, from extracts of sponge. ##STR1##

REFERENCES:
patent: 4731377 (1988-03-01), Higa et al.
Kobayashi et al., CA: 121: 35137 (1993)-Abstract of Chem. Pharm. Bull. (1993), 41(7), 1324-6.

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