Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1994-08-10
1997-10-07
Ulm, John
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
436822, G01N 33566
Patent
active
056747535
ABSTRACT:
Diagnostic/prognostic methods are provided for detecting and/or quantitating in the body fluids, preferably serum, of mammals carrying a malignant tumor burden, elevated levels of a portion of the epidermal growth factor receptor (EGFr) which comprises substantially the EGFr ectodomain having a molecular weight in the range of from about 90 kilodaltons (kd) to about 115 kd, preferably from about 95 kd to about 105 kd, and more preferably about 100 kd. Substantially pure compositions comprising EGFr ectodoman protein and/or fragments thereof are disclosed as well as test kits for performing the disclosed assays.
REFERENCES:
patent: 4699877 (1987-10-01), Cline et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 4943533 (1990-07-01), Mendelsohn et al.
patent: 5221612 (1993-06-01), Zhau et al.
Di Fiora et al., Cell 51:1063-1070, 24 Dec. 1987.
Adamson and Rees, "Epidermal growth factor receptors", Molecular and Cellular Biochemistry, 34: 129-152 (1981).
Brauknect et al., "Occurrence of Epidermal Growth Factor Receptors in Human Adnexal Tumors and Their Prognostic Value in Advanced Ovarian Carcinomas", Gynecologic Oncology, 29: 147-157 (1988).
Berger et al., "Epidermal Growth Factor Receptors in Lung Tumours", Journal of Pathology, 152: 297-307 (1987).
Carlin and Knowles, "Identity of human epidermal growth factor (EGF) receptor with glycoprotein SA-7: Evidence for differential phosphorylation of the two components of the EGF receptor from A31 cells", PNAS (USA), 79: 5026-6030 (Aug. 1982).
Cohen et al., "A Native 170,000 Epidermal Growth Factor Receptor-Kinase Complex from Shed Plasma Membrane Vesicles", Journal of Biological Chemistry, 257(3): 1523-1531 (Feb. 19, 1982).
Cooper et al., "Epidermal Growth Factor Receptor Metabolism and Protein Kinase Activity in Human A431 Cells Infected with Snyder-Theilen Feline Sarcoma Virus or Harvey or Kirsten Murine Sarcoma Virus", Journal of Virology, 48: 752-764 (Dec. 1983).
Downward et al., "Close similarity of epidermal growth factor receptor and v-erbB oncogene protein sequences", Nature, 307(5951); 521-527 (1984).
Fabricant et al., "Nerve growth factor receptors on human melanoma cells in culture", PNAS (USA) 74(2): 565-569 (Feb. 1977).
Fitzpatrick et al., "Epidermal Growth Factor Binding by Breast Tumor Biopsies and Relationship to Estrogen Receptor and Progestin Receptor Levels", Cancer Research, 44: 3348-3453 (Aug. 1984).
Grimaux et al., "A Simplified Immuno-Enzymetric Assay of the Epidermal Growth Factor Receptor in Breast Tumors: Evaluation in 282 Cases", Int. J. Cancer: 45: 255-262 (1990).
Gullick et al., "A Radioimmunoassay for Human Epidermal Growth Factor Receptor", Analytical Biochemistry, 141: 253-261 (1984).
Gullick et al., "The structure and function of the epidermal growth factor receptor studied by using antisynthetic peptide antibodies", Proc. R. Soc. Lond., B226: 127-134 (1985).
Gullick et al., "Expression of Epidermal Growth Factor Receptors on Human Cervical, Ovarian and Vulval Carcinomas", Cancer Research, 46: 285-292 (Jan. 1986).
Gullick and Waterfield, "Epidermal growth factor and its receptor", Chapter 1, pp. 15-34 in Ellis Horward Series In Biomedicine: The Molecular Biology of Receptors. Techniques and Applications of Receptor Research (Stresberg ed.) (VCH Publishers Inc. NY, NY 1987).
Hapgood et al., "Monoclonal antibodies against epidermal growth factor receptor induce prolactin synthesis in cultured rat pituitary cells (GH.sub.3)", PNAS (USA), 80: 6451-6455 (Nov. 1983).
Hendler and Ozanne, "Human Squamous Cell Lung Cancers Express Increased Epidermal Growth Factor Receptors", J. Clin. Inves., 74: 647-651 (1984).
Humphrey et al., "Amplification and Expression of the Epidermal Growth Factor Receptor Gene in Human Glioma Xenografts", Cancer Research, 48: 2231-2238 (Apr. 15, 1988).
Humphrey et al., "Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma", PNAS (USA), 87: 4207-4211 (Jun. 1990).
Kawawato et al., "Growth stimulation of A431 cells by epidermal growth factor: Identification of high-affinity receptors for epidermal growth factor by an anti-receptor monoclonal antibody", PNAS (USA), 80: 1337-1341 (Mar. 1983).
Libermann et al., "Expression of Epidermal Growth Factor Receptors in Human Brain Tumors", Cancer Research, 44: 753-760 (Feb. 1984).
Lin et al., "Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells", Science, 224: 843-847 (May 25, 1994).
Malden et al., "Selective Amplification of the Cytoplasmic Domain of the Epidermal Growth Factor Receptor Gene in Glioblastoma Multiforme", Cancer Research, 48: 2711-2714 (May 15, 1988).
Mayes and Waterfield, "Biosynthesis of the epidermal growth factor receptor in A431 cells", EMBO, J., 3: 531-537 (1984).
Merlino et al., "Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells", Science, 229: 417-419 (Apr. 27, 1984).
Neal et al. "Epidermal-Growth-Factor Receptors in Human Bladder Cancer: Comparison of Invasive and Superficial Tumours", Lancet, 1(8425): 366-368 (Feb. 16, 1985).
Nicholson et al., "Quantitative Assays of Epidermal Growth Factor Receptor in Human Breast Cancer: Cut-off Points of Clinical Relevance", Int. J. Cancer, 42: 36-41 (1988).
Nicholson et al., "Expression of Epidermal Growth Factor Receptors Associated with Lack of Response to Endocrine Therapy in Recurrent Breast Cancer", Lancet. 1(8631): 182-185 (Jan. 28, 1989).
Parker et al., "Monoclonal Antibodies against the Human Epidermal Growth Factor Receptor from A431 Cells", Journal of Biological Chemistry, 259(15): 9906-9912 (Aug. 10, 1984).
Perez, et al., "Epidermal growth factor receptors in human breast Cancer", Breast Cancer Research Treatment, 4: 189-193 (1984).
Petch et al., "A Truncated, Secreted Form of the Epidermal Growth Factor Receptor Is Encoded by an Alternatively Spliced Transcript in Normal Rat Tissue", Molecular and Cellular Biology, 10(6): 2973-2982 (Jun. 1990).
Richert et al., "Epidermal Growth Factor Receptor", Journal of Biological Chemistry, 258: 8902-8907 (1983).
Sainsbury et al., "Epidermal-Growth-Factor Receptor Status as Predicator of Early Recurrence of the Death from Breast Cancer", Lancet, 1(8547): 1398-1402 (Jun. 20, 1987).
Sohreiber et al., "Monoclonal antibodies against receptor for epidermal growth factor induce early and delayed effects of epidermal groth factor", PNAS (USA), 78(12): 7535-7539 (Dec. 1981).
Smith et al., "Characterization and Quantitation of the Epidermal Growth Factor Receptor in Invasive and Superficial Bladder Tumors", Cancer Research, 49: 5810-5815 (1989).
Stoscheck and Carpenter, "Down Regulation of Epidermal Growth Factor Receptors: Direct Demonstration of Receptor Degradation in Human Fibroblasts", Journal of Cell Biology, 98: 1048-1053 (Mar. 1984).
Thompson and Gill, "The EGF receptor: structure, regulation and potential role in malignancy", Cancer Surveys, 4(4): 767-788 (1985).
Ullrich et al., "Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells", Nature, 309 (5967): 418-425 (May 31, 1984).
Waterfield et al., "Anti Epidermal Growth Factor Receptor Monoclonal Antibodies", Cell Biology International Reports, 7(7): 535-537 (Jul. 1983).
Waterfield et al., "Anti-epidermal-growth-factor receptor monoclonal antibodies", Chemical Abstracts, 99(19): 156453e (p. 455) (Nov. 7, 1983).
Waterfield, et al., "A Monoclonal Antibody to the Human Epidermal Growth Factor Receptor", Journal of Cellular Biochemistry, 20: 149-161 (1982).
Weber et al., "Production of an Epidermal Growth Factor Receptor-Related Protein", Science, 224: 294-297 (Apr. 20, 1984).
Weber, "Truncated EGF receptor: functional aspects of its secretion", Acta Endocrino Logica, 177 (Suppl. 287): 47 (No. 55) 1988).
Wrann and Fox, "Identification of Epidermal Growth Factor Receptors in a Hyperproducing Human Epidermoid Carcinoma Cell Line", Journal of Biological Chemistry, 254(17): 8083-
Crebbin Victoria A.
Hammond Susan L.
Harvey Jeanne P.
Liu Victor
McDonald Patricia A.
Chiron Diagnostics Corporation
Lauder Leona L.
Morgenstern Arthur S.
Ulm John
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