Epidermal growth factor inhibitor

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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530350, 530399, 530417, A61K 3816, C07K 1447, C07K 120, C07K 130

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active

055501141

ABSTRACT:
A protein which inhibits Epidermal Growth Factor-induced cellular proliferation is disclosed, also a method of producing the protein in virus-infected host cells, including purifying the protein such as by using C18 reverse phase HPLC. Additionally, therapeutic uses of the protein also are described.

REFERENCES:
patent: 4230727 (1980-10-01), Nuss, Jr. et al.
patent: 4289690 (1981-09-01), Pestka et al.
patent: 4462986 (1984-07-01), Smith
patent: 4569935 (1986-02-01), Rosenberg et al.
patent: 4606917 (1986-08-01), Eppstein
patent: 4929442 (1990-05-01), Powell
patent: 4997929 (1991-03-01), Collins et al.
patent: 5126323 (1992-06-01), Rogers et al.
patent: 5216176 (1993-06-01), Heindel et al.
patent: 5242921 (1993-09-01), Milstone et al.
Sofer et al BioTechniques, Nov./Dec. 1983 pp. 198-203.
Laurence, D. J. R., Gusterson, B. A.: The Epidermal Growth Factor. Tumor Biol. (1990), 11:229-261.
Coleman, S., Silberstein, G. B., Daniel, C. W.: Ductal Morphogenesis in the Mouse Mammary Gland: Evidence Supporting a Role for Epidermal Growth Factor. Dev. Biol., (1988), 127:304-315.
Taub, M., Wang, Y., Szcaesny, T. M., Kleinman, H. K.: Epidermal Growth Factor or Transforming Growth Factor .alpha. is Required for Kidney Tubulogenesis in Matrigel Cultures in Serum-Free Medium. Proc. Natl. Acad. Sci. (1990) 87:4002-4006.
Greenfield, C., Hiles, I., Waterfield, M. D., Federwisch, M., Wollmer, A., Blundell, T. L., McDonald, N.: Epidermal Growth Factor Binding Induces a Conformational Change in the External Domain of its Receptor. EMBO J., (1989), 8:4115-4123.
Nickoloff, B. J., Mitra, R. S.: Inhibition of .sup.125 I-Epidermal Growth Factor Binding to Cultured Keratinocytes by Antiproliferative Molecules Gamma Interferon, Cyclosporin A, and Transforming Growth Factor-Beta. J. Invest., Dermatol. (1989), 93:799-803.
Imamoto, A., Beltran, L. M., DiGiovanni, J.: Differential Mechanism for the Inhibition of Epidermal Growth Factor Binding to its Receptor on Mouse Keratinocytes by Anthrones and Phorbol Esters. Carcinogenesis (1990), 11:1543-1549.
Hori, T., Kashiyama, S., Hayakawa, M., Shimbamoto, S., Tsujimoto, M., Oku, N., Ito, F.: Possible Role of Prostaglandins as Negative Regulators in Growth Stimulation by Tumor Necrosis Factor and Epidermal Growth Factor in Human Fibroblasts. J. Cell. Physiol. (1989), 141:275-280.
Murthy, U., Rieman, D. J., Rodeck, U.: Inhibition of TGF Alpha-Induced Second Messengers by Anti-EGF Receptor Anti-Body-425. Biochem. Biophys. Res. Comm. (1990), 172:471-476.
Rodeck, U., Williams, N., Murthy, U., Herlyn, M.: Monoclonal Antibody 425 Inhibits Growth Stimulation of Carcinoma Cells by Exopenous EGF and Tumor-Derived EGF-TGF-Alpha. J. Cell. Biochem. (1990), 44:69-79.
Ennis, B. W., Valverius, E. M., Bates, S. E., Lippman, M. E., Bellot F., Kris, R., Schlessinger, J., Masui, H., Goldenberg, A., Mendelsohn, J., Dickson, R. B.: Anti-Epidermal Growth Factor Receptor Antibodies Inhibit the Autocrine-Stimulated Growth of MDA-468 Human Breast Cancer Cells. Molec. Endocrinol. (1989), 3:1830-1838.
Elizalde, P. V., Charreau, E. H.: Alpha-Transforming Growth Factor Like Activities and Bifunctional Regulators of Cell Growth in Human Malignant Neoplasms. Cancer Invest. (1990), 8:365-374.
Matsunami, R. K., Campion, S. R., Niyogi, S. K., Stevens, A.: Analogs of Human Epidermal Growth Factor Which Partially Inhibit the Growth Factor-Dependent Protein-Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor. FEBS Letters (1990), 264:105-108.
Eppstein, D. A., Marsh, Y. V., Schryver, B. B., Bertics, P. J.: Inhibition of Epidermal Growth Factor/Transforming Growth Factor-.alpha.-Stimulated Cell Growth by a Synthetic Peptide. J. Cell. Physiol. (1989), 141:420-430.
Strayer, D. S., Leibowitz, J. L.: Inhibition of Epidermal Growth Factor-Induced cellular Proliferation. Am. J. Pathol. (1987), 128:203-209.
Strayer, D. S., Skaletsky, E., Cabirac, G., Sharp, P. A., Corbeil, L. B., Sell, S., Leibowitz, J. L.: Malignant Rabbit Fibroma Virus Causes Secondary Immunosuppression in Rabbits. J. Immunol. (1983), 130:399-404.
Twardzik, D. R., Brown, J. P., Ranchalis, J. E., Todaro, G. J., Moss, B.: Vaccinia Virus-Infected Cells Release a Novel Polypeptide Functionally Related to Transforming and Epidermal Growth Factors. Proc. Natl. Acad. Sci. (1985) 83:5300-5304.
Stroobant, P., Rice, A. P., Gullick, W. J., Cheng, D. J., Kerr, I. M., Waterfield, M. D.: Purification and Characterization of Vaccinia Virus Growth Factor. Cell, (1985), 42:383-393.
Towbin, H., Staheiln, T., Gordon, J.: Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications. Proc. Natl. Acad. Sci. (1979) 76:4350-4354.
Matsudaira, P.: Sequence from Picomole Quantities of Proteins Electroblotted Onto Polyvinylidene Difluoride Membranes. J. Biol. Chem. (1987), 261:10035-10038.
Pearson, W. R., Lipman, D. J.: Improved Tools for Biological Sequence Comparison. Proc. Natl. Acad. Sci. (1988), 85:2444-2448.
Drivas, G. T., Shih, A., Coutavas, E., Rush, M. G., D'Eustachio, P.: Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line. Mol. Cell. Biol. (1990), 10:1793-1798.
Bischoff, F. R., Ponstingl, H.: Catalysis of Guanine Nucleotide Exchange on Ran by the Mitotic Regulator RCC1. Nature (1991), 354:80-82.
Downward, J., Parker, P., Waterfield, M. D.: Autophosphorylation Sites on the Epidermal Growth Factor Receptor. Nature (1984), 311:483-485.
Ahn, N. G., Weiel, J. E., Chan, C. P., Krebs, E. G.: Identification of Multiple Epidermal Growth Factor-Stimulated Protein Serine/Threonine Kinases from Swiss 3T3 Cells. J. Biol. Chem. (1990), 265:11487-11494.
Ahn, N. G., Krebs, E. G.: Evidence for an Epidermal Growth Factor-Stimulated Protein Kinase Cascade in Swiss 3T3 Cells. J. Biol. Chem. (1990), 265:11495-11501.

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