Epidermal differentiation factor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.

Reexamination Certificate

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C530S350000

Reexamination Certificate

active

07071312

ABSTRACT:
A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

REFERENCES:
patent: 5434064 (1995-07-01), Schlessinger
patent: 5872234 (1999-02-01), Bandman
patent: 6303765 (2001-10-01), Bandman et al.
patent: WO-00/55633 (2000-09-01), None
Fuchs, E., Current Opinion in Cell Biology, 2:1028-10354 (1990).
Fuchs, E.J., J. Cell Biol., 111 (6/Pt. 2):2807-2814 (1990).
Backendorf, et al., Nature Genetics, 2:91 (1992).
Steinert, et al., Intl. J. Macromol., 13(3):130-139 (1991).
Volz, et al., Genomics, 18:92-99 (1993).
Johnson, et al., The 46th Annual Meeting of the American Society of Human Genetics, San Francisco, CA, Abstract No. 2316 (1996).
Smits, et al., The 25th European Symposium on Calcified Tissues, European Calcified Tissue Society, Harrogate, UK, Abstract No. P222 (1997).
Johnson, et al., Genbank Accession No. U65934 (Aug. 13, 1996).
Johnson, et al., Genbank Accession No. U65932 (Aug. 13, 1996).
Genbank Accession No. Q16610 (1996).
GenBank Accession No. R83319, “yp82e01.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image:193944 3′, mRNA sequence,” Hillier, et al. (Aug. 4, 1995).
Bhalerao, et al., J. Biol. Chem., 270:16385-16394.
GenBank Accession No. R98765, “yq67d11.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image:100853 3′, mRNA sequence,” Hillier, et al. (Sep. 13, 1995).
GenBank Accession No. N71368, “za31b08.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image:294135 3′, mRNA sequence,” Hillier, et al. (Mar. 14, 1996).
GenBank Accession No. N71317, “za30b08.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image:193944 3′, mRNA sequence,” Hillier, et al. (Mar. 14, 1996).
GenBank Accession No. H66729, “yr83e091.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image:211912 3′, mRNA sequence,” Hiller, et al. (Oct. 18, 1995).
GenBank Accession No. R62808, “yi11c04.sl Soares placenta Nb2HP Homo sapiens cDNA clone Image:138918 3′, mRNA sequence,” Hiller, et al. (May 26, 1995).
GenBank Accession No. H66472, “yu51h12.sl Soares fetal liver spleen INFLSHomo sapienscDNA clone Image: 229703 3′, mRNA sequence,” Hillier, et al. (Oct. 18, 1995).
Deckers, et al., “Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and minerlization of mouse embryonic metatarsals in vitro,” Bone, 28(1):14-20 (2001).
Locus Link Locus ID:1893, “ECM1:extracellular matrix protein 1,” NCBI.
OMIM Accession No. 602201, “Extracellular matrix protein 1; ECM1,” Johns Hopkins University (Jan. 12, 1998).
GenBank Accession No. NM—04425, “Homo sapiensextracellular matrix protein 1 (ECM1), transcript variant 1” (Feb. 7, 2001).
GenBank Accession No. NP—04416, “Extracellular matrix protein 1, isoform 1 precursor; secretory component p85” (Feb. 7, 2001).
GenBank Accession No. NM—022664, “Homo sapiensextracellular matrix protein 1 (ECM1) transcript variant 2” (Feb. 7, 2001).
GenBank Accession No. NP—073155, “Extracellular matrix protein 1, isoform 2 precursor; secretory component p85” (Feb. 7, 2001).
Smits, et al., “Differentiation-dependent alternative splicing and expression of the extracellular matrix protein 1 gene in human keratinocytes,” J. Investigative Dermatology, 114(4):718-724 (2000).
Han, et al., “Extracellular matrix protein 1 (ECM1) has angiogenic properties and is expressed by breast tumor cells,” FASEB Journal, 15:988-994 (2001).
Smits, et al., “The human extracellular matrix gene 1 (ECM1): genomic structure, cDNA cloning, expression pattern, and chromosomal localization,” Genomics, 45:487-495 (1997).
Hamada, et al., “Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1),” Hum. Mol. Gen., 11(7):833-840 (2002).

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