EphA4 Antibodies

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof

Reexamination Certificate

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Details

C424S143100, C424S174100, C530S387100, C530S388100, C530S388800

Reexamination Certificate

active

07604799

ABSTRACT:
The invention provides agonistic anti-EphA4 antibodies.

REFERENCES:
patent: 5322798 (1994-06-01), Sadowski
patent: 5341215 (1994-08-01), Seher
patent: 6268125 (2001-07-01), Perkins
patent: 6289286 (2001-09-01), Andersson et al.
patent: 6373577 (2002-04-01), Brauer et al.
patent: 6984720 (2006-01-01), Korman et al.
patent: 2003/0224374 (2003-12-01), Dai et al.
patent: 2004/0028685 (2004-02-01), Kinch et al.
patent: 2004/0180823 (2004-09-01), Pasquale et al.
patent: WO 99/54440 (1999-10-01), None
patent: WO 01/00678 (2001-01-01), None
patent: WO 01/94629 (2001-12-01), None
Freshney (Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p4).
Dermer (Bio/Technology, 1994, 12:320)
Kipps et al (J Exp Med, 1988, 167:840-852).
Easty et al (Int J Cancer, 1997, 71:1061-1065, IDS).
iHOP, EphA4, 2 pages.
Rudikoff et al, PNAS, USA, 1982, 79: 1979-1983.
Panka et al (Proc Natl Acad Sci, 1988, 85:3080-3084).
MacCallum et al (J Mol Biology, 1996, 262:732-745).
Easty et al (Int J Cancer, 1997, 71:1061-1065, IDS).
iHOP, p.1.
Freitas et al, Dev Genes Evol, 2004, 214:466-472.
Kultima et al (BMC Bioinformatics, 2006, 7:475, internet pp. 1-27).
Sambrook et al. (Molecular Cloning, 2nd edition, Cold Spring Harbor Press, 1989, p. 18.47).
Invitrogen™ product information sheet for protein standards and ladders, p. 1-4.
Wada et al (Developmental Biology, 1998, 202:244-252).
U.S. Appl. No. 60/622,711, filed Oct. 27, 2004, Kinch.
U.S. Appl. No. 60/503,356, filed Sep. 16, 2003, Carles-Kinch et al.
U.S. Appl. No. 60/476,909, filed Jun. 6, 2003, Carles-Kinch et al.
U.S. Appl. No. 09/952,560, filed Sep. 12, 2001, Kilpatrick et al.
Ashida et al., 2004, “Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINs,” Cancer Res. 64(17):5963-5972.
Burridge et al., 1996, “Focal adhesions, contractility, and signaling,” Annu. Rev. Cell Dev. Biol. 12:463-518.
Cance et al., 1995, “Protein kinases in human breast cancer,” Breast Cancer Res. Treat. 35(1):105-114.
Chaiken et al., 1992, “Analysis of macromolecular interactions using immobilized ligands,” Anal. Biochem. 201(2):197-210.
Cheng et al., 2002, “The ephrins and Eph receptors in angiogenesis,” Cytokine Growth Factor Rev. 13(1):75-85.
Dong et al., 2002, “Some new aspects in biosensors,” J. Biotechnol. 82(4):303-323.
Easty et al., 1997, “Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma,” Int. J. Cancer 71(6):1061-1065.
Ellis et al., 1996, “A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn,” Oncogene 12(8):1727-1736.
Fisher et al., 1994, “Surface plasmon resonance based methods for measuring the kinetics and binding affinities of biomolecular interactions,” Curr. Opin. Biotechnol. 5(4):389-395.
Fivash et al., 1998, “BIAcore for macromolecular interaction,” Curr. Opin. Biotechnol. 9(1):97-101.
Fox et al., 1995, “cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases,” Oncogene 10(5):897-905.
Fry et al., 1995, “Inhibitors of protein tyrosine kinases,” Curr. Opin. Biotechnol. 6(6):662-667.
Haseloff et al., 1988, “Simple RNA enzymes with new and highly specific endoribonuclease activities,” Nature 334(6183):585-591.
Hunter, 1997, “Oncoprotein networks,” Cell 88(3):333-346.
Kinch et al., 2003, “Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer,” Clin. Exp. Metastasis 20(1):59-68.
Kondapaka et al., 1996, “Tyrosine kinase inhibitor as a novel signal transduction and antiproliferative agent: prostate cancer,” Mol. Cell. Endocrinol. 117(1):53-58.
Kuang et al., 1998, “Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line,” Nucleic Acids Res. 26(4):1116-1123.
Levitzki et al., 1995, “Tyrosine kinase inhibition: an approach to drug development,” Science 267(5205):1782-1788.
Logsdon et al., 2003, “Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer,” Cancer Res. 63(10):2649-2657.
Malik et al., 1996, “Integrin-mediated signaling in normal and malignant cells: a role of protein tyrosine kinases,” Biochim. Biophys. Acta 1287(2-3):73-76.
Martone et al., 1997, “Immunolocalization of the receptor tyrosine kinase EphA4 in the adult rat central nervous system,” Brain Res. 771(2):238-250.
Meric et al., 2002, “Expression profile of tyrosine kinases in breast cancer,” Clin. Cancer. Res. 8(2):361-367.
Miao et al., 2000, “Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation,” Nat. Cell Biol. 2(2):62-69.
Morton et al., 1995, “Interpreting complex binding kinetics from optical biosensors: a comparison of analysis by linearization, the integrated rate equation, and numerical integration,” Anal. Biochem. 227(1):176-185.
Mullett et al., 2000, “Surface plasmon resonance-based immunoassays,” Methods 22(1):77-91.
Myszka, 1997, “Kinetic analysis of macromolecular interactions using surface plasmon resonance biosensors,” Curr. Opin. Biotechnol. 8(1):50-57.
Nemoto et al., 1997, “Overexpression of protein tyrosine kinases in human esophageal cancer,” Pathobiology 65(4):195-203.
O'Shannessy, 1994, “Determination of kinetic rate and equilibrium binding constants for macromolecular interactions: a critique of the surface plasmon resonance literature,” Curr. Opin. Biotechnol. 5(1):65-71.
Parsons, 1996, “Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins,” Curr. Opin. Cell Biol. 8(2):146-152.
Pasquale, 1997, “The Eph family receptors,” Curr. Opin. Cell. Biol. 9(5):608-615.
Patarca, 1996, “Protein phosphorylation and dephosphorylation in physiologic and oncologic processes,” Crit. Rev. Oncog. 7(5-6):343-432.
Rhim et al., 1997, “Human prostate carcinogenesis,” Crit. Rev. Oncog. 8(4):305-328.
Rich et al., 2000, “Advances in surface plasmon resonance biosensor analysis,” Curr. Opin. Biotechnol. 11(1):54-61.
Winning et al., 2002, “EphA4 catalytic activity causes inhibition of RhoA GTPase in Xenopus laevis embryos,” Differentiation 70(1):46-55.
Zelinski et al., 2001, “EphA2 overexpression causes tumorigenesis of mammary epithelial cells,” Cancer Res. 61(5):2301-2306.

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