Ependymal neural stem cells and method for their isolation

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S368000, C435S381000

Reexamination Certificate

active

10183728

ABSTRACT:
The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.

REFERENCES:
patent: 5753505 (1998-05-01), Luskin
patent: 5753506 (1998-05-01), Johe
patent: 5851832 (1998-12-01), Weiss et al.
patent: 2003/0129747 (2003-07-01), Frisen et al.
patent: WO94/02593 (1994-02-01), None
patent: WO95/13364 (1995-05-01), None
patent: WO97/09885 (1997-03-01), None
patent: WO97/11716 (1997-04-01), None
patent: WO97/44442 (1997-11-01), None
patent: WO99/16863 (1999-04-01), None
Vogel, Science, vol. 290 (2000) pp. 1672-1674.
U.S. Appl. No. 09/104,772, filed Jun. 25, 1998, Frisen et al.
Date, 1996, Parkinson's Disease, Trophic Factors, and Adrenal Medullary Chromaffin Cell Grating: Basic and Clinical Studies,Brain Research Bulletin40(1):1-19.
Goldman et al., 1998, Strategies utilized by migrating neurons of the postnatal vertebrate forebrain,TINS21(3):107-114.
Hagan et al., 1997, “Parkinson's disease: prospects for improved drug therapy,”TiPS18:156-163.
McKay, 1997, “Stem Cells in the Central Nervous System,”Science276:66-71.
Mehta et al., 1997, “Neural Transplantation in Parkinson's Disease,”Can. J. Neurol. Sci.24:292-301.
Morrison et al., 1997, “Regulatory Mechanisms in Stem Cell Biology,”Cell88:287-298.
Reynolds and Weiss, 1992, “Generation of Neurons and Astrocytes from isolated Cells of the Adult Mammalian Central Nervous System”, Science 255:1707-1710.
Lindsell et al., 1996, “Expression patterns of Jagged, Delta 1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development.” Mol Cell Neurosci. 8(1):14-27.
Higuchi et al., 1995, “Differential expression of Notch1 and Notch2 in developing and adult mouse brain.” Brain Res Mol Brain Res. 29(2):263-72.
Alvarez-Buylla A, Lois C., 1995, “Neuronal stem cells in the brain of adult vertebrates.” Stem Cells. May;13(3):263-72. Review.
Alvarez-Buylla et al., 1998, “Primary neural precursors and intermitotic nuclear migration in the ventricular zone of adult Canaries.” J Neurosci. 18(3):1020-37.
Weiss et al., 1996, “Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis.” J Neurosci. Dec. 1;16(23):7599-609.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ependymal neural stem cells and method for their isolation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ependymal neural stem cells and method for their isolation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ependymal neural stem cells and method for their isolation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3947929

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.