EP2 receptor agonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S268400, C546S290000, C546S304000

Reexamination Certificate

active

07662839

ABSTRACT:
A compound of formula (I):or a salt, or chemically protected form thereof, wherein: R5is an optionally substituted phenyl;A is wherein Q is N; R3is selected from H, F, Cl and optionally substituted C1-4alkyl, C1-4alkoxy, C5-7aryl, and C5-7aryl-C1-4alkyl groups; R4is selected from H, F, Cl and optionally substituted C1-4alkyl, C1-4alkoxy, C5-7aryl, and C5-7aryl-C1-4alkyl groups; R6is selected from H, F, Cl, and optionally substituted C1-4alkyl, C1-4alkoxy, C5-7aryl, and C5-7aryl-C1-4alkyl groups;D is selected from:B is selected from the group consisting of:Where RN′is selected from H and C1-4alkyl; where one of RP3and RP4is —Cm-alkylene-R2and the other of RP3and RP4is H, m and n can be 0 or 1, and m+n=1 or 2; and additionally, when RP3is —Cm-alkylene-R2, m can also be 2 or 3, and m+n=1, 2, 3 or 4, and when R2is tetrazol-5-yl, m+n may be 0; or where one of RP3and RP4is —O—CH2—R2, and the other of RP3and RP4is H, n is 0; RNis H or optionally substituted C1-4alkyl; R2is either: (i) —CO2H; (ii) —CONH2; (iii) —CH2—OH; or (iv) tetrazol-5-yl.

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