EP 4 receptor agonist, compositions and methods thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S096000, C544S097000, C544S044000, C544S059000, C546S243000, C514S227200, C514S227500, C514S227800, C514S315000, C514S317000

Reexamination Certificate

active

07053085

ABSTRACT:
This invention relates to potent selective agonists of the EP4subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

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