Eosinophilotactic tetrapeptides

Details Eosinophilotactic tetrapeptides Eosinophilotactic tetrapeptides

1975-11-19

1977-05-03

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

260 6, 2601125R, 424177, C07C10352, C08H 100

Patent

active

040213870

ABSTRACT:
Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu have been isolated from extracts of human lung fragments. These tetrapeptides have been synthesized by solid phase peptide synthesis procedures and the synthetic and natural materials behaved similarly in analytical assays and bioassays. Novel N-terminal analogs have been prepared and have shown eosinophilotactic activity. Thus, the tetrapeptides disclosed herein have utility as therapeutic agents in the prophylaxis and/or treatment of parasitic diseases, anaphylaxis and bronchial asthma.

REFERENCES:
kay et al., J. Exp. Med., 133, 602-619 (1971).
J. M. Stewart and J. D. Young, "Solid Phase Peptide Synthesis," Freeman and Co., San Francisco, 1969, pp. 9-13.

Affiliated with

Also associated with

Rating

Eosinophilotactic tetrapeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Eosinophilotactic tetrapeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Eosinophilotactic tetrapeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-344425