Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Patent
1988-12-22
1991-12-03
Elmore, Carolyn
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
435122, 435130, 435134, 435135, 546174, 546175, C12P 4100
Patent
active
050700227
ABSTRACT:
Disclosed is a process for preparing the R and S enantiomers of a compound of the formula; ##STR1## which comprises; (1) reacting an enzyme with a prochiral diester of the formula ##STR2## where M.sup.1 and M.sup.2 are the same, to produce a chiral monoester of the compound of formula II;
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Amato Joseph S.
Bergan James J.
Grabowski Edward J. J.
Hughes David L.
Reider Paul J.
DiPrima Joseph F.
Elmore Carolyn
Lopez Gabriel
Merck & Co. , Inc.
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