Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-11-14
1999-06-15
Low, Christopher S. F.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435190, 435189, 435 691, 4351723, 4353201, 43525233, 536 232, 930240, 935 10, 935 14, C12N 121, C12N 904, C07H 2104
Patent
active
059121610
ABSTRACT:
Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
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Anderson Stephen
Hurle Mark
Lazarus Robert A.
Powers David B.
Low Christopher S. F.
Rutgers The State University of New Jersey
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