Enzymes for breaking down moenomycins

Details Enzymes for breaking down moenomycins Enzymes for breaking down moenomycins

1992-09-03

1993-11-09

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435194, 435196, 435199, 4352525, 435832, C12N 120, C12N 914, C12P 1944, C12P 742

Patent

active

052602060

ABSTRACT:
A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylas inhibitors.

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G. Huber, Antibiotics, 1:135-153 (1979).
Fehlhaber et al., "Moenomycin A: A Structural Revision And New Structure-Activity Relations," Tetrahedron, 46(5):1557-1568 (1990).
A. L. Lehninger, Biochemistry, Second Edition, pp. 195-197 (1970).
Takahashi et al., "Structure of Pholipomycin," Tetrahedron 24(5):499-502 (1983).

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