Enzyme PDE XVI

Details Enzyme PDE XVI Enzyme PDE XVI

2006-08-15

2006-08-15

Saidha, Tekchand (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07091024

ABSTRACT:
Amino acid sequences and nucleotide sequences relating to PDE_XIV are described. In a preferred aspect, the amino acid sequences comprise the sequence presented as SEQ ID NO:1 or SEQ ID NO:3 or SEQ ID NO:5.

REFERENCES:
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patent: 6146876 (2000-11-01), Robision et al.
patent: WO 9735989 (1997-10-01), None
patent: WO 0077226 (2000-12-01), None
Beavo, et al.,Physiological Reviews, Cyclic Nucleotide Phosphodiesterases: Functional implications of multiple isoforms, vol. 75(4): 725-748, 1995.
Bloom, et al.,Proc. Natl. Acad. Sci. USA, Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants, vol. 99: 14188-14192, 1996.
Database EMBL, Accession No. L 12052: Michaeli T. ‘Homo sapiens cAMP phosphodiesterase PDE7(PDE7A1)mRNA, complete cds.’, Mar. 9, 1993.
Database EMBL, Accession No. U68171: Bloom T.J. and Beavo J.A. ‘Mus musculus cyclic nucleotide phosphodiesterase PDE7A2(MMPDE7A)mRNA, complete cds.’, Sep. 20, 1996.
Database EMBL, Accession No. Q13946: ‘High-affinity cAMP-specific 3′,5′-cyclic phosphodiesterase 7A’, Jul. 15, 1998.
Han, et al.,Journal of Biological Chemistry, Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart, vol. 272(26): 16152-16157, 1997.
Michaeli, et al.,Journal of Biological Chemistry, Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient saccharomyces cerevisiae, vol. 268(17): 12925-12932, 1993.
Nucleotide sequence database EMBL ID AI006099, Accession No. AI006099 Jun. 15, 1998, XP002105162.

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