Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1989-05-10
1991-03-26
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435 711, 435 712, 435212, 435219, 435220, 435909, C12P 2100, C12R 163
Patent
active
050028723
ABSTRACT:
Disclosed herein is an enzymatic process to bind two amino acids in the presence of a water-miscible solvent. Preferably the amino acids are precursors of aspartame and a preferred solvent is acetonitrile.
REFERENCES:
patent: 3972773 (1976-08-01), Isowa et al.
patent: 4086136 (1978-04-01), Isowa et al.
patent: 4116768 (1978-09-01), Isowa et al.
patent: 4119493 (1978-10-01), Isowa et al.
patent: 4165311 (1979-08-01), Isowa et al.
patent: 4256836 (1981-03-01), Isowa et al.
patent: 4284721 (1981-08-01), Oyama et al.
patent: 4293648 (1981-10-01), Davino
patent: 4339534 (1982-07-01), Johansen et al.
patent: 4436925 (1984-03-01), Isowa et al.
patent: 4521514 (1985-06-01), Oyama et al.
patent: 4572894 (1986-02-01), Imahori et al.
Biotech Derwent Abs. 89-02943 Reslow et al., EJBCAI Eur. J. Biochem (1988) 177, 2, 313-318.
Biotech Derwent Abs. 85-179237/30 Likos et al., EP-149594, Jul. 1985.
Biotech Abs. Derwent 89-14093 Coccak Collect Czech Chem. Commun. (1989) 54, 7, 2027-41 Cerovsky et al.
Elphinoff-Felkin; "Synthesis of erythro-Beta-phenylserine", 232/241-43, 1951.
Chang et al.; "The Hydrogenation of Alpha-Oximino Ketones"; J. Am. Chem. Soc., vol. 75, pp. 89-91; 1951.
Jones et al.; "Asymmetric Synthesis and Resolutions Using Enzymes"; Appl. Biolchem. Sys., p. 107; 1953.
Isowa et al.; "Peptide Synthesis with Proteinases, Fragment Condensation of ZleuGlnGlyOH or ZGlnGlyOH with HLeuValNH.sub.2, Using Metalloproteinases"; Bull. Chem. Soc., vol. 51, pp. 271-276; 1978.
Inouye et al.; "Enzyme Assisted Semisynthesis of Human Insulin"; J. Am. Chem. Soc., pp. 751-752; 1979.
Jones et al.; "Effects of Organic Cosolvents on enzyme stereospecificity, The Enantiomeric specificity of alpha-chymotrypsin is Reduced by High Organic Solvent Concentrations"; Can. J. Chem., vol. 57, p. 2245, 1979.
Kullman; "Proteases as Catalysts for Enzymatic Synthesis of Opioid Peptides"; J. Biol. Chem.; vol. 255/8234-38; 1980.
Kullman; "Protease-Mediated Peptide Bond Formation"; J. Biol. Chem.; vol. 256/1301-04; 1981.
Konnecke et al.; "Peptide Synthesis by Means of Immobilized Enzymes"; Monatschrifts Fur Chemie; vol. 112/469-81; 1981.
Wayne et al.; "Thermolysin-Catalyzed Peptide Bond Synthesis"; Proc. Nat. Acad. Sci., vol. 80/3241; 1983.
Nilsson et al.; Biotech. Bioeng., vol. 26/1146; 1984 "Peptide Synthesis in Aqueous-Organic Solvent Mixtures with alpha-Chymotrypsin Immobilized to Tresyl Chloride-Activated Agarose".
Cerovosky et al., "Enzymatically Catalyzed Synthesis of Dipeptides of -carboxy-L-Glutamic Acid from Benzyloxycarbonyl-y-Carboxy-DL-Glutamic-Acid"; Coll. Czechos. Chem., vol. 49/231, 1984.
Ooshima et al.; "Synthesis of Aspartame Precursor by Solid Thermolysin In Organic Solvent"; Biotech. Lett.; vol. 7/789, 1985.
Jakubke et al.; "Basic Principles of Protease-Catalysed Peptide Bond Formation"; Angew, Chem., vol. 24/85, 1985.
West et al.; "Enzyme-Catalyzed Irreversible Formation of Peptides Containing D-Amino Acids"; J. Org. Chem., vol. 51/2728, 1986.
Klibanov et al.; "Enzymes that Work in Organic Solvents"; Chemtech., p. 354, 1986.
U.S. Application 789,593-Chmurny et al.
U.S. Application 789,595-Chmurny et al.
Oyama, "Biocat.-Org. Media", pp. 209-224, 1987.
Rodgers et al., "Biocat.-Org. Media", pp. 405-409, 1987.
Appleby Vanessa L.
Krafte Jill H.
Lilling Herbert J.
Trinker Steven T.
W. R. Grace & Co.,-Conn.
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