Enzyme-inhibitory griseolic acid derivatives, and their use

Details Enzyme-inhibitory griseolic acid derivatives, and their use Enzyme-inhibitory griseolic acid derivatives, and their use

1987-12-11

1989-04-18

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

435119, 536 22, 536 26, C07D 1940, C07H 1702

Patent

active

048228796

ABSTRACT:
Dihydrodesoxygriseolic acid, which has the formula ##STR1## and salts and esters thereof may be prepared by cultivating a suitable strain of Streptomyces, e.g. Streptomyces griseoaurantiacus No. 43894, and, if necessary, salifying or esterifying the free acid. These compounds inhibit the activity of various cyclic nucleotide phosphodiesterases, particularly cAMP PDE, and, as a result of this, have a variety of physiological activities and uses.

REFERENCES:
patent: 4460765 (1984-07-01), Naito et al.

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