Enzyme inhibitors and methods therefor

Details Enzyme inhibitors and methods therefor Enzyme inhibitors and methods therefor

2005-08-02

2005-08-02

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S064000, C568S001000

Reexamination Certificate

active

06924269

ABSTRACT:
An enzyme is inhibited by presenting the enzyme with a boron containing structure having a tetrahedral boron atom covalently bound to four ligands. Particularly preferred enzymes include prostaglandin endoperoxide synthase (COX-1 and COX-2), and particularly preferred structures include a ligand that confers at least 80-fold selectivity of COX-2 inhibition over COX-1 inhibition. Consequently, further methods are directed towards induction of apoptosis in a cell and methods of reducing pain.

REFERENCES:
patent: 5312816 (1994-05-01), Spielvogel et al.
patent: 6080425 (2000-06-01), Miljkovic et al.
Sui et al. (Bioorganic & Medicinal Chemistry, Dec. 1993, vol. 1 (6), pp. 415-422) (Abstract Sent).
Murmu et al. (Journal of Experimental & Clinical Cancer Research (2001), 20 (4), 511-515) (Abstract Sent).

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