Enzyme inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C546S146000, C546S304000, C548S492000, C549S057000, C562S450000

Reexamination Certificate

active

07939666

ABSTRACT:
Compounds of formula (I) are inhibitors of histone deacetylase activity, and are useful in the treatment of, for example, cancers.

REFERENCES:
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patent: WO 2005/037272 (2005-04-01), None
Vippagunta et al., Advanced Drug Delivery Reviews, vol. 48, (2001), pp. 3-26.
Tamaki Kazuhiko et al., “Synthesis and structure-activity relationships of gelatinase inhibitors derived from matlystatins” Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, Tokyo, JP, vol. 43, No. 11, 1995, pp. 1883-1893, XP002165817.
Wolz Russel L, “A kinetic comparison of the homologous proteases astacin and meprin A1” Archives of Biochemistry and Biophysics, vol. 310, No. 1, 1994, pp. 144-151, XP002392032.
Inaoka Y et al., “Propioxatins A and B, New Enkephalinase B Inhibitors. IV. Characterization of the Active Site of the Enzyme Using Synthetic Propioxatin Analogues” Nov. 1988, Journal of Biochemistry, Japanese Biochemical Society/ OUP, Tokyo, JP, pp. 706-711 XP000978993.

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