Enzyme inhibitors

Details Enzyme inhibitors Enzyme inhibitors

1983-02-01

1987-03-17

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514 16, 514 17, 530323, 530328, 530329, A61K 4900, A61K 3743, C07K 502, C07K 706

Patent

active

046506616

ABSTRACT:
Renin inhibitory polypeptide analogues derived from the natural N-terminal substrate sequence by replacing the amino acid at position 10 with statine or a residue related to it.

REFERENCES:
patent: 4198398 (1980-04-01), Hudson et al.
patent: 4424207 (1984-01-01), Szelke et al.
patent: 4470971 (1984-09-01), Boger et al.
Parsons, Peptide Hormones, University Park Press, Baltimore, pp. 1-7.
Ariens, Drug Design, II, Academic Press, Inc. N.Y. 1971, Chapter 9, p. 337.
Blundell et al., Nature, vol. 304, 1983, pp. 273-275.
Nishizawa et al., Journal of Medicinal Chemistry, vol. 20, No. 4, 1977, pp. 510-515.
Rich et al., Biochemical and Biophysical Research Communications, vol. 74, No. 2, 1977, pp. 762-767.
Rich et al., J. Org. Chem., vol. 43, No. 18, 1978, pp. 3624-3626.

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