Enzyme inhibitors

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...

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Details

2601125R, 2601125E, C07C10352, A61K 3702

Patent

active

044242077

ABSTRACT:
Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 11 peptide link of the substrate, and preparation of dipeptide analogues.

REFERENCES:
patent: 4198398 (1980-04-01), Hudson et al.
patent: 4242256 (1980-12-01), Sharpe et al.

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