Enzyme inhibitor produced by cultivation of streptomyces microor

Details Enzyme inhibitor produced by cultivation of streptomyces microor Enzyme inhibitor produced by cultivation of streptomyces microor

1982-05-12

1984-07-17

Wiseman, Thomas G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 88, 435119, 435128, 435253, 435886, 536 24, 544277, C12D 1940, C07H 1702, C12P 1718, C12R 1465

Patent

active

044607652

ABSTRACT:
A new compound, named "Griseolic acid", and its salts and can be prepared by the cultivation of Streptomyces griseoaurantiacus SANK 63479 (FERM-P 5223). Griseolic acid and its salts inhibit the activity of the enzyme cyclic adenosine monophosphate phosphodiesterase and, as a result of this, have variety of physiological activities and uses.

REFERENCES:
patent: 4104462 (1978-08-01), Fisher et al.
Amer et al, "Cyclic Nucleotide Phosphodiesterases: Properties, Activators Inhibitors, Structure-Activity RElationships and . . . ", Journal of Pharmaceutical Sciences 64(1) (1975) pp. 1-37.
Shuman et al, "Synthesis and Biological Activity of Some Purine 5'-thio-5'-deoxynucleoside 3', 5'-cyclic Phosphothionates", Biochemistry 12(15) (1973) pp. 2781-2786.

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