Enzyme-inhibiting urea derivatives of dipeptides, a process for

Details Enzyme-inhibiting urea derivatives of dipeptides, a process for Enzyme-inhibiting urea derivatives of dipeptides, a process for

1989-12-07

1992-05-26

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142278, 5142358, 5142365, 5142355, 514255, 514256, 514316, 514318, 514326, 514341, 514343, 514365, 514397, 540575, 540596, 540597, 540598, 540601, 540602, 540603, 544 60, 544121, 544129, 544132, 544133, 544141, 544295, 544333, 544335, 544357, 544360, 544364, 544365, 544370, 544371, 544372, 544374, 544379, 546187, 546189, 546193, 546194, 546208, 546209, 546210, 546211, 546278, 546281, 548336, A61K 3155, A61K 31535, C07D24308, C07D41700

Patent

active

051168359

ABSTRACT:
Enzyme-inhibiting urea derivatives of dipeptides, a process for the preparation thereof, agents containing these, and the use thereof.
The present invention relates to compounds of the formula I ##STR1## in which A and B denote, indpendently of one another, an amino acid,

REFERENCES:
patent: 4725583 (1988-02-01), Luly et al.
patent: 4812555 (1989-03-01), Raddatz et al.
patent: 4840935 (1989-06-01), Wagnon et al.
patent: 4855286 (1989-08-01), Wagner
Haher, "Renin Inhibitors", J. Cardiovascular Phermacology, 10 Supp. 7 (S54-58) 1987.
Bolis, "Renis Inhibitors & Dipeptids of Angiotensinogen" J. Med. Chem. 1987, 30, 1729-1737.
J. Med. Chem. 1988, 31, 2277-2288 Burger, "Med. Chem." 2nd edition, Interscience Publisher Jun. 27, 1960. NY p. 565.
Denkewalter, "Program in Drug Research" vol. 10, 1966 p. 510.

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