Enzyme Inhibiting substance

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549549, A61K 31355, C07D30348

Patent

active

047329106

ABSTRACT:
A substance is provided which has strong enzyme inhibitory activity against thiol proteases such as papain, ficin, bromelain, etc. and which is represented by the following formula: ##STR1## (wherein R is a hydrogen atom or a hydroxyl group), its pharmaceutically acceptable salt or hydrate.

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Carl R. Noller, "Chemistry of Organic Compounds", (1965), W. B. Saunders Company, p. 439.
W. H. Johnson et al., J. Chem. Soc., (C) , (1971), pp. 748-753.
99Agric. Biol. Chem., 42, (3), 523-536, 1978.
The Journal of Antibiotics, 25, 263-266, 1972.
Abstracts of J55035012; J54141795; J52031024; J54141734; J54141737; J54141750.

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