Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-03-05
1987-02-24
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 28, 436511, G01N 3353, G01N 33534, G01N 33535, G01N 33571
Patent
active
046457372
ABSTRACT:
A method for the determination of anti-treponemal antibody in a test sample comprises contacting a substrate for the anti-treponemal antibody with sample; treating the contacted substrate with labeled antihuman Ig antibody selected from (a) a mixture comprising enzyme labeled antihuman Ig antibody and fluorescent labeled antihuman Ig antibody, (b) antihuman Ig antibody labeled with an enzyme and a fluorescent label, and (c) fluorescent labeled antihuman Ig antibody to which enzyme labeled antibody against the animal species from which the antibody used in the fluorescent labeled antibody was derived is added subsequently, and (d) enzyme labeled antihuman Ig antibody to which fluorescent labeled antibody against the animal species from which the antibody used in the enzyme labeled antibody was derived is subsequently added; determining the enzyme activity of the treated substrate; and determining the immunofluorescent patterns in substrates exhibiting enzyme activity. The method is useful for the rapid screening of anti-treponemal antibodies for the diagnosis of syphilis.
REFERENCES:
patent: 4041146 (1977-08-01), Gaever
patent: 4144031 (1979-03-01), Acevedo
patent: 4228127 (1980-10-01), Acevedo
patent: 4288426 (1981-09-01), Stevens
patent: 4487830 (1984-12-01), Coates et al.
Binder Walter L.
Coates Stephen R.
American Hoechst Corporation
Marantz Sidney
Rosenstock Jerome
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