Enzyme immobilization for producing cephalosporin antibiotics

Details Enzyme immobilization for producing cephalosporin antibiotics Enzyme immobilization for producing cephalosporin antibiotics

1986-01-23

1987-09-15

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

435 43, 435 47, 435 49, 435177, 435815, 435816, 435886, C12N 1108, C12N 1102, C12P 3700, C12R 1465

Patent

active

046939776

ABSTRACT:
Enzymes extracted from a prokaryotic .beta.-lactam producing microorganism are immobilized on a support for producing desacetoxycephalosporin and analogs thereof from L-.alpha.-aminoadipyl-L-cysteinyl-D-valine and analogs thereof. The enzymes are an epimerase, a cyclase and a ring expansion enzyme extracted preferably from S. clavuligerus, S. cattleya or S. lipmanii. The support is preferably a diethylaminoethyl ion exchange resin.

REFERENCES:
patent: 4075061 (1978-02-01), Fleming et al.
patent: 4178210 (1979-12-01), Demain et al.
patent: 4248966 (1981-02-01), Demain et al.
patent: 4307192 (1981-12-01), Demain et al.
patent: 4510246 (1985-04-01), Wolfe et al.
Chibata, I., Immobilized Enzymes, Research and Development, John Wiley & Sons, N.Y., 1978, pp. 9-15 & 198-201.

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