Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Reexamination Certificate
2007-02-06
2007-02-06
Nguyen, Nam (Department: 1753)
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
C204S600000, C435S175000, C435S176000
Reexamination Certificate
active
10351976
ABSTRACT:
Disclosed herein is a method and apparatus of immobilizing a biocatalyst on a microfluidic biochip for conducting reactions in the presence of electroosmotic flow. The biochip includes a polymer on its microfluidic flow surfaces, wherein the polymer includes a first substituent selected from ionic groups of the same polarity or precursors thereof, a second substituent that is a hydrophobic group, and a third substituent comprising an immobilized biocatalyst-or precursor thereof. The biochip can be used to conduct multiple sequential biocatalyzed reactions in the presence of electroosmotic flow.
REFERENCES:
patent: 3650900 (1972-03-01), Levin et al.
patent: 5181999 (1993-01-01), Wiktorowicz
patent: 5885470 (1999-03-01), Parce et al.
patent: 6403368 (2002-06-01), Jan et al.
patent: 6582969 (2003-06-01), Wagner et al.
patent: 2002/0185184 (2002-12-01), O'Connor et al.
patent: 2004/0121491 (2004-06-01), Marchand-Brynaert et al.
patent: 0 452 055 (1995-01-01), None
patent: 1 274 869 (1972-05-01), None
patent: 11-164687 (1999-06-01), None
patent: WO/01/14437 (2000-08-01), None
patent: WO 00/62051 (2000-10-01), None
Miller, Scott A., and Martin, Charles R., “Controlling the rate and direction of electroosmotic flow in template-prepared carbon nanotube membranes”, Mar. 22, 2002, Journal of Electroanalytical Chemistry, vol. 522, pp. 66-69.
Drott, J., et al., “Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities,”J. Micromech. Microeng., 7:14-23 (1997).
Haswell, S.J. and Skelton, V., “Chemical and biochemical microreactors,”Trends in Analytical Chemistry, 19(6): 389-395 (2000).
Laurell, T., et al., “Silicon wafer integrated enzyme reactors,”Biosensors&Bioelectronics, 10: 289-299 (1995).
Liu, Y., et al., “Dynamic coating using polyelectrolyte multilayers for chemical control of electroosmotic flow in capillary electrophoresis microchips,”Analytical Chemistry, 72(24):5939-5944 (2000).
Nagy, G., et al., “Amperometric microcell for enzyme activity measurements,”Analytical Chemistry, 70(10):2156-2162 (1998).
Park, C.B. and Clark, D.S., “Sol-gel encapsulated enzyme arrays for high-throughput screening of biocatalytic activity,”Biotechnology and Bioengineering, 78(2): 231-235 (2002).
Dordick Jonathan S.
Ku Bosung
Lee Moo-Yeal
Srinivasan Aravind
Elmore Carolyn S.
Elmore Patent Law Group P.C.
Fick Anthony
Nguyen Nam
Rensselaer Polytechnic Institute
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