Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2008-07-29
2008-07-29
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
Reexamination Certificate
active
07405065
ABSTRACT:
The invention relates to a novel process for the preparation of (1R,4S)- or (1S,4R)-1-amino-4-(hydroxy-methyl)-2-cyclopentene of the formulaeand/or of (1S,4R)- or (1R,4S)-amino alcohol derivatives of the general formulaeand to novel microorganisms which are able to utilize a cyclopentene derivative of the general formulaas sole nitrogen source, as sole carbon source or as sole carbon and nitrogen source.
REFERENCES:
patent: WO 91/01318 (1991-02-01), None
patent: WO 91/01319 (1991-02-01), None
patent: WO 91/15447 (1991-10-01), None
patent: WO 93/17020 (1993-09-01), None
Sakanyan et al., “Gene Cloning, Sequence Analysis, Purification, and Characterization of a Thermostable Aminoacylase fromBacillus stearothermophilus”, Applied and Evironmental Microbiology 59 (11): 3878-3888 (1993).
Martinez et al., 1996, “Highly efficient and enantioselective synthesis of carbocylic nucleoside analogs using selective early transition metal catalysis”, J. Org. Chem.61:7963-7966.
Campbell et al., 1995, Chirospecific synthesis of precursors of cyclopentane and cyclopentane carbocyclic nucleosides by [3+3]-coupling and transannular alkylation, J. Org. Chem. 60:4602-4616.
Park et al., 1994, “Enantioselective synthesis of (1R,4S)-1-amino-4(hydroxymethyl)-2-cyclopentane, a precursor for carbocyclic nucleoside synthesis”, J. Org. Chem. 59:394-399.
Taylor, et al., 1993, Development of the biocatalytic resolution of 2-azabicyclo[2.2.1]hept-5-en-3-one as an entry to single enantiomer carbocyclic nucleosides, Tetrahedron: Asymmetry 4: 1117-1128.
Norman et al., 1992, “Novel synthesis of (+/−)-cis-4-amino-2-cyclopentene-1-methanol, a key intermediate in the preparation of carbocyclic 2′,3′-didehydro-2′,3′-dideoxy nucleosides”, Synthetic Communications 22, 3197-3204.
Bernegger-Egli Christine
Birch Olwen M.
Bossard Pierre
Brieden Walter
Brux Frank
Baker & Botts LLP
Lonza AG
Saucier Sandra
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