Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2003-03-26
2009-08-11
Saucier, Sandra (Department: 1651)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
Reexamination Certificate
active
07572439
ABSTRACT:
Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.
REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4847325 (1989-07-01), Shadle et al.
patent: 4931390 (1990-06-01), Recsei
patent: 4980163 (1990-12-01), Blackburn et al.
patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5234903 (1993-08-01), Nho et al.
patent: 5760026 (1998-06-01), Blackburn et al.
patent: 5820607 (1998-10-01), Tcholakian et al.
patent: 5858962 (1999-01-01), Blackburn et al.
patent: 6028051 (2000-02-01), Climo et al.
patent: 6315996 (2001-11-01), O'Callaghan
patent: 7151139 (2006-12-01), Tiller et al.
patent: 2002/0006406 (2002-01-01), Goldstein et al.
patent: 2002/0037260 (2002-03-01), Budny et al.
patent: 2003/0229000 (2003-12-01), Merritt et al.
patent: 01/04287 (2001-01-01), None
Gander et al. “An investitation of the antimicrobial effects of linezolid on bacterial biofilms utilizing an in vitro pharmacokinetic model” J. Antimicrobial Chemotherapy (2002) 49: 301-308.
Christensen et al. “Adherence of Coagulase-negative staphylococci to plastic . . .” J. Clin. Microbiol. (1985) 22(6): 996-1006.
S. Zalipsky, “Functionalized Poly (ethylene glycol) for Preparation of Biologically Relevant Conjugates,”Bioconjugate Chem., 6, 150-165 (1995).
A. Thierry, S. Pinaud, N. Bigler, G. Perrenoud, B. Denis, M. Roggero, N. Fasel, C. Moulon, S. Demotz, “Long Synthetic Peptides as Biologically Active Proteins: The Example of the Chemokines,”Biologicals, 29 (3-4), 259-263 (2001).
H. Gaertner, R. Offord, “Site-Specific Attachment of Functionalized Poly (ethylene glycol) to the amino Terminus of Proteins,”Bioconjugate Chem., 7, 38-44 (1996).
International Search Report for PCT/US03/09354, issued Aug. 21, 2003.
Adams Julie M.
Chanturiya Tanya I.
Kokai-Kun John F.
Mond James J.
Shah Anjali G.
Biosynexus Incorporated
Casimir Jones S.C.
Hanley Susan
Saucier Sandra
LandOfFree
Enzyme disruption of bacterial biofilms does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enzyme disruption of bacterial biofilms, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enzyme disruption of bacterial biofilms will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4095934