Enzyme derived from hyaluronidase

Details Enzyme derived from hyaluronidase Enzyme derived from hyaluronidase

1981-11-23

1983-10-18

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435201, A61K 3748, C12N 926

Patent

active

044105312

ABSTRACT:
The present invention provides an enzyme which is an odorless, white powder, the pH of a 15000 to 22000 IU/ml. solution of which in carbon dioxide-free physiological saline solution suitable for injection is 4.5 to 7.5, the solution being clear and colorless; a solution of 50000 IU of which in 3 ml. carbon dioxide-free physiological saline solution suitable for injection has a light absorption of not more than 0.60 at 280 nm and of not more than 0.37 at 260 nm; the enzyme having the following percentage amino acid analysis:

REFERENCES:
patent: 2488565 (1949-11-01), Singher et al.
patent: 2808362 (1957-10-01), Thompson et al.
patent: 3728223 (1973-04-01), Kaneko et al.

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