Enzyme derivatives for use in the treatment of venous thrombosis

Details Enzyme derivatives for use in the treatment of venous thrombosis Enzyme derivatives for use in the treatment of venous thrombosis

1980-12-16

1982-06-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3748

Patent

active

043372449

ABSTRACT:
Prophylactic or therapeutic method for the treatment of venous thrombosis by administering preferably intravenously to a human in need thereof a pharmaceutically acceptable carrier and an in vivo fibrinolytic enzyme in which the catalytic site essential for fibrinolytic activity is blocked by a group, such as an acyl group, removable by hydrolysis at a rate such that the pseudo-first order rate constant for hydrolysis is in the range of 10.sup.-6 sec.sup.-1 to 10.sup.-3 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C.

REFERENCES:
Malen, et al., Chem. Abstr. vol. 76, 1972, 858108.
Chem. Abstr. vol. 78, 1973, 699v, 53467z.
Chem. Abstr. vol. 82, 1975, 106973c.
Chase, Jr., et al., Biochemistry 8, 1969, 2212-2224.

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