Enzyme deregulation

Details Enzyme deregulation Enzyme deregulation

1986-05-07

1988-06-28

Kight, John

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Lyase

435233, 435317, 530350, C12N 988, C12N 990, C07K 1300

Patent

active

047538830

ABSTRACT:
Proteins having chorismate mutase-prephenate dehydratase (CMPD) activity, but lacking phenylalanine sensitivity are produced by genetic engineering. The proteins contain a sequence substantially corresponding to the N-terminal 337 amino acids of Escherichia coli CMPD. Expression vectors including genes coding for those proteins and regulatory DNA enabling their expression are used to transform host microorganisms, which are cultured to produce phenylalanine.

REFERENCES:
Hudson and Davidson, J. Mol. Biol. 180:1023-1051 (1984).
Baldwin et al. Arch. Biochem. Biophys. 211:66-85 (1981).
Gething and Davidson, Eur. J. Biochem. 86:159-164 (1978).
Gething and Davidson Eur. J. Biochem. 86:165-174 (1978).
Gething and Davidson Eur. J. Biochem. 78:111-117 (1977).

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