Enzyme conjugates

Details Enzyme conjugates Enzyme conjugates

1974-10-21

1977-01-11

Naff, David M.

Textiles: fiber preparation

195 63, 195 68, 195DIG11, 1951035R, 260112R, 424 12, G01N 3114, C07G 702

Patent

active

040025322

ABSTRACT:
This invention relates to the provision of enzyme-macromolecule conjugates by conjugation with polyfunctional reagents in the presence of organic compounds which act as conditioners. Conjugation of enzymes with antibodies in the presence of conditioner yields conjugates with increased immunological specificity. Organic polyamines of either high or low molecular weight are conditioners. Conditioners are especially useful for conjugation of polymeric and unstable enzymes such as .beta.-D-galactosidase. The high degree of immunospecificity and sensitivity achieved with conditioners yields conjugates suitable for detection and quantification of substances, such as IgE, in nanogram quantities in biological fluids with many interfering substances.

REFERENCES:
patent: 3639558 (1972-02-01), Csizmas et al.
patent: 3654090 (1972-04-01), Schuurs et al.
patent: 3839153 (1974-10-01), Schuurs et al.
patent: 3859169 (1975-01-01), O'Driscoll et al.
Arrameas et al., Biologically Active Water-Insoluble Protein Polymers, J. of Biol. Chem., vol. 242, No. 7, 1967, (pp. 1651-1659).

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