Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1998-10-02
1999-11-09
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435174, 435177, 435213, 435219, 435221, 435222, C12P 762, C12N 950
Patent
active
059812400
ABSTRACT:
A method is described for a simple, fast and efficient synthesis of homopolymers and copolymers by the enzymatic ring opening polymerization of lactones and lactides. The enzyme used is an ion paired protease. The advantage of this enzymatic system is in using small amount of enzyme per monomer and lower reaction time. Homopolymers and copolymers are synthesized with molecular weights between 1000 and 4600 daltons, and dispersity as low as 1.1. The monomer conversion after 4 days, for reactions catalyzed by protease S, has reached 100%. Different initiators are used to control the rate and degree of polymerization. Synthesis of block copolymers with defined block size and crystallinity are described in this invention. These biodegradable and bioerodable polyesters and copolyesters with controlled molecular weight, dispersity and crystallinity have applications in medical, drug, cosmetic and food industries.
REFERENCES:
patent: 5719039 (1998-02-01), Dordick et al.
Derwent Computer Biotechds 93-01794 Rao Et Al "The Use Of Pressure To Mod Enzyme Activity In Reversed Micelles; Prssurization Of Lipase And Chymotrypsin-Containing Aot-Water Isooctane Reversed Micelle May Be Used As A Switch For Lipase Reactions" Biot, 1992.
Derwent Computer Biotechnds 94-04152 Paradkar Et Al "Mechanism Of Extraction Of Chymotrypsin Into Isooctane At Very Low Concentrations Of Aerosol Ot In The Absence Of Reversed Micelles. . " Biotechnol Bioeng. (1994) 43, 6, 529-540, 1994.
Akkara Joseph A.
Bruno Ferdinando F.
Lilling Herbert J.
Ranucci Vincent J.
The United States of America as represented by the Secretary of
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