Enzyme-based fluorescence biosensor for chemical analysis

Details Enzyme-based fluorescence biosensor for chemical analysis Enzyme-based fluorescence biosensor for chemical analysis

1996-10-25

1999-09-14

Achutamurthy, Ponnathapura

Chemistry: analytical and immunological testing

Metal or metal containing

Organometallic compound determined

436 76, 436 74, 436 73, 436501, 530413, 530412, 530350, G01N 3348

Patent

active

059522364

ABSTRACT:
This invention generally relates to the detection, determination, and quantitation of certain ions and small molecules involving the quenching of a fluorescent label attached to a macromolecule, often due to fluorescence energy transfer to a colored inhibitor or certain metal ions bound to the macromolecule.

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Thompson et al., "Enzyme-Based Fiber Optic Zinc Biosensor" Anal. Chem. (1993) 65:730-734.
Thompson et al., "Lifetime-Based Fluorescence Energy Transfer Biosensing of Zinc" Anal. Biochem., (1995) 227:123-128.
Thompson et al., "Performance Enhancement of Fluorescence Energy Transfer-Based Biosensors by Site-Directed Mutagenesis of the Transducer" J. Biomed. Optics, (1996) 1:131-137.
Thompson, et al., "Structure-Based Design of a Sulfonamide Probe for Fluorescence Anisotropy Detection of Zinc with a Carbonic Anhydrase-Based Biosensor" J. Am. Chem. Soc., (1996) 118:8381-8387.
Thompson et al., "Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer," Biosensors & Bioelec. (1996) 11:557-564.
Thompson et al., "Site-Specific Mutants of Carbonic Anhydrase for Fluorescence Energy Transfer-Based Metal Ion Biosensing" SPIE, (1995) 2508:136-144.

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