Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase
Reexamination Certificate
2008-03-04
2008-03-04
Gitomer, Ralph (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving transferase
Reexamination Certificate
active
11351899
ABSTRACT:
An assay and kit for determining the activity of an enzyme such as kinase, ATPase and GTPase is disclosed. The assay and kit are useful in drug screening to select modulators of such an enzyme.
REFERENCES:
patent: 4235961 (1980-11-01), Lundin
patent: 4923796 (1990-05-01), Deneke et al.
patent: 5124141 (1992-06-01), Makler
patent: 5286627 (1994-02-01), Ueda et al.
patent: 5698685 (1997-12-01), Summerton et al.
patent: 5750344 (1998-05-01), Doyle
patent: 5766963 (1998-06-01), Baldwin et al.
patent: 5780256 (1998-07-01), Ueda et al.
patent: 5792821 (1998-08-01), Bowen
patent: 5798214 (1998-08-01), Squirrell
patent: 5834318 (1998-11-01), Buettner
patent: 5866341 (1999-02-01), Spinella et al.
patent: 5877278 (1999-03-01), Zuckermann et al.
patent: 5916761 (1999-06-01), Koga et al.
patent: 5962337 (1999-10-01), Ohlmeyer
patent: 5968787 (1999-10-01), Iwata et al.
patent: 6015561 (2000-01-01), Alvarez
patent: 6022713 (2000-02-01), Noguchi et al.
patent: 6093798 (2000-07-01), Floyd et al.
patent: 6107059 (2000-08-01), Hart
patent: 6156511 (2000-12-01), Schatz et al.
patent: 6162926 (2000-12-01), Murphy et al.
patent: 6306617 (2001-10-01), Gunzer et al.
patent: 6380380 (2002-04-01), Kaufman
patent: 6413733 (2002-07-01), Nagel et al.
patent: 6599711 (2003-07-01), Crouch et al.
patent: 2002/0172991 (2002-11-01), Crouch et al.
Hillard et al. Talanta 1998;45:507-512.
Maeda et al. Chem. Pharm. Bull. 2001;49(5):622-625.
Batchelor et al., “A resorufin-based fluorescent assay for quantifying NADH”,Anal Biochem., Jun. 2002, 305(1):118-119.
Bunin et al., “A General and Expedient Method for the Solid-Phase Synthesis of 1,4-Benzodiazepine Derivatives”,J. Am. Chem. Soc., 1992, 114:10997-10998.
Devlin et al., “Random peptide libraries: a source of specific protein binding molecules”,Science, Jul. 1990, 249:404-406.
Gallop et al., “Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries”,Journal of Medicinal Chemistry, Apr. 29, 1994, 37(9):1233-1251.
Gold, “Oligonucleotides as Research, Diagnostic, and Therapeutic Agents”,The Journal of Biological Chemistry, Jun. 9, 1995, 270(23):13581-13584.
Gordon et al., “Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions”, Journal of Medicinal Chemistry, May 13, 1994, 37(10):1385-1401.
Graves et al., “Protein phosphorylation and signal transduction”,Pharmacol. Ther., May-Jun. 1999, 82(2-3):111-121.
Kao et al., “Engineered biosynthesis of a complete macrolactone in a heterologous host”,Science, Jul. 1994, 265:509-512.
Koga et al., “Biochemical Characterization, Cloning, and Sequencing of ADP-Dependent (AMP-Forming) Glucokinase from Two Hyperthermophilic Archaea,Pyrococcus furiosusandThermococcus litoralis1”,J. Biochem., 2000, 128:1079-1085.
Kengen et al., “Purification and Characterization of a Novel ADP-dependent Glucokinase from the Hyperthermophilic ArchaeonPyrococcus furiosus”, The Journal of Biological Chemistry, Dec. 22, 1995, 270(51):30453-30457.
Lei et al., “Mechanism of Reduced Flavin Transfer fromVibrio harveyiNADPH-FMN Oxidoreductase to Luciferase”,Biochemistry, 1998, 37:14623-14629.
McDaniel et al., “Engineered biosynthesis of novel polyketides”,Science, Dec. 3, 1993, 262:1546-1550.
Moran et al., “Radio Frequency Tag Encoded Combinatorial Library Method for the Discovery of Tripeptide-Substituted Cinnamic Acid Inhibitors of the Protein Tyrosine Phosphatase PTP1B”,J. Am. Chem., 1995, 117:10787-10788.
Sakuraba et al., “ADP-dependent Glucokinase/Phosphofructokinase, a Novel Bifunctional Enzyme from the Hperthermophilic ArchaeonMethanococcus jannaschii”, The Journal of Biological Chemistry, Apr. 22, 2002, 277(15):12495-12498.
Schenk et al., “Signal perception and transduction: the role of protein kinases”,Biochim Biophys Acta., Feb. 4, 1999, 1449(1):1-24.
Scott et al., “Searching for peptide ligands with an epitope library”,Science, Jul. 27, 1990, 249:386-390.
Simon et al., “Peptoids: A modular approach to drug discovery”,Proc. Natl. Sci., Oct. 1992, 89:9367-9371.
Srinivasan et al., “ADP-Specific Sensors Enable Universal Assay of Protein Kinase Activity”.Chemistry&Biology, Apr. 2004, 11:449-508.
Stachelhaus et al., “Rational design of peptide antibiotics by targeted replacement of bacterial and fungal domains”,Science, Jul. 7, 1995, 269:69-72.
Thelen et al., “Molecular Cloning and Expression Analysis of the Mitochondrial Pyruvate Dehydrogenase from Maize1”,Plant Physiology, Feb. 1999, 119:635-643.
Tuininga et al., “Molecular and Biochemical Characterization of the ADP-dependent Phosphofructokinase from the Hyperthermophilic ArchaeonPyrococcus furiosus”, The Journal of Biological Chemistry, Jul. 23, 1999, 274(30):21023-21028.
Tornheim et al., “Specific Enzymatic Spectrophotometric Assay of Adenosine 5′- Diphosphate”,Analytical Biochemistry, 1993, 211:329-330.
Verhees et al., “Biochemical adaptations of two sugar kinases from the hyperthermophilic archaeonPyrococcus furiosus”, Biochem. J., 2002, 366:121-127.
“ADP Hunter Assay 90-0077, Fluorescence Intensity Detection”,DiscoverRx, Product Information Sheet, Aug. 16, 2005, pp. 1-6.
“Kinase-Glo Luminescent Kinase Assay”,Promega, Product Information Sheet, Dec. 2002, pp. 1-12.
TK Substrate Quest Kit, Fluorescence Intensity Detection, Product code 90-0072,DiscoverRx, Product Information Sheet, Aug. 2005, pp. 1-6.
“Vybrant Cytotoxicity Assay Kit (V-23111)”,Molecular Probes, Product Information Sheet, Jul. 2002, pp. 1-3.
Hunsaker Thomas
Ostanin Kirill
Gibbs Andrew
Gitomer Ralph
Myriad Genetics Inc.
Myriad IP Department
Shen Bin
LandOfFree
Enzyme assay and use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Enzyme assay and use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Enzyme assay and use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3930212