Enzyme activated nitric oxide donors

Details Enzyme activated nitric oxide donors Enzyme activated nitric oxide donors

2005-03-15

2005-03-15

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S017500, C536S118000, C536S119000, C536S124000, C536S017300, C536S018700, C536S020000, C536S023100, C435S097000, C435S193000, C510S392000, C510S310000, C526S238200

Reexamination Certificate

active

06867194

ABSTRACT:
Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the sugar-modified SIN-1 compositions and methods of using the compositions are also provided.

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Xuejun Wu, et al, “Glycosylated diazenlumdiolates: a novel class of enzyme activated nitric oxide donors,” Tetrahedron Letters 2001, 42, 3779-3782.
Carlos A. Valdez, et al., “Carbohydrates as Novel Diazeniumdiolate Protecting Groups,” American Chemical Society Meeting at Chicago, Jul. 20, 2001. Abstract # 43. Division of Carbohydrate Chemistry.
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Saavedra, Joseph, et al., “Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family: In Vitro Antileukemic Activity,”J. Med. Chem. 2000, 43, 261-269.
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