Enzymatically-produced dimeric IL-2 and a nerve-derived transglu

Details Enzymatically-produced dimeric IL-2 and a nerve-derived transglu Enzymatically-produced dimeric IL-2 and a nerve-derived transglu

1993-07-30

1996-05-07

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C12P 2102

Patent

active

055145655

ABSTRACT:
The invention provides a new nerve-derived transglutaminase enzyme that converts immune-derived IL-2 to dimeric IL-2 having oligodendrocyte cytotoxic activity. Both the nerve-derived transglutaminase and the dimeric mammalian, e.g. human, IL-2, are for use as active ingredients in pharmaceutical compositions for inducing and facilitating regeneration of injured nerves of the central nervous system in mammals.

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