Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1983-09-19
1986-05-20
Apley, Richard J.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 1, 623 66, 128334R, 128 1R, 424 36, 514 12, 514 17, 530330, 530345, 530409, A61F 202, A61F 206, A61K 3700
Patent
active
045898820
ABSTRACT:
A method of repairing a natural elastic system in a human or animal body, which comprises replacing a damaged portion of the system with a shaped artificial elastomeric copolymer comprising an elastomeric component selected from the group consisting of tetrapeptide and pentapeptide repeating units or mixtures thereof wherein the repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues and the repeating units exist in a conformation having a .beta.-turn and a crosslinking component selected from the group consisting of amino acid and peptide residues of the formula ##STR1## wherein .alpha. represents a covalent bond or a peptide fragment containing 1-10 .alpha.-helix-forming amino acid residues, B represents a covalent bond or a petide fragment containing 1-10 amino acid residues, and n is an integer from 2 to 6; wherein the copolymer optionally comprises a chemotactic component selected from the group consisting of -Ala-Pro-Gly-Val-Gly-Val-, -Pro-Gly-Val-Gly-Val-Ala-, -Gly-Val-Gly-Val-Ala-Pro-, -Val-Gly-Val-Ala-Pro-Gly-, -Gly-Val-Ala-Pro-Gly-Val-, and -Val-Ala-Pro-Gly-Val-Gly- and is essentially devoid of peptide fragments which occur in natural elastin other than these elastomeric, crosslinking, and chemotactic components, is disclosed along with elastomeric copolymers suitable for use in the method of the invention and methods of synthesizing such bioelastomers.
REFERENCES:
patent: 4132746 (1979-01-01), Urry et al.
patent: 4187852 (1980-02-01), Urry et al.
patent: 4500700 (1985-02-01), Urry
Apley Richard J.
Beaucage Gregory
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