Enzymatically active recombinant human acetylcholinesterase and

Details Enzymatically active recombinant human acetylcholinesterase and Enzymatically active recombinant human acetylcholinesterase and

1991-07-22

1993-09-28

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352523, 43525233, 4353201, C12N 918, C12N 1570

Patent

active

052486044

ABSTRACT:
The subject invention provides an enzymatically active nonglycosylated, recombinant, human acetylcholinesterase comprising at least one polypeptide characterized by an amino acid sequence which is substantially identical to the amino acid sequence of naturally-occurring human acetylcholinesterase. The subject invention additionally provides an enzymatically active recombinant human acetylcholinesterase comprising at least one polypeptide characterized by an amino acid sequence in which serine is substituted for cys 611 in the sequence of naturally-occurring, human acetylcholinesterase and an enzymatically active recombinant human acetylcholinesterase comprising at least one polypeptide characterized by the presence of a methionine of the N-terminus of the amino acid sequence of naturally-occurring human acetylcholinesterase.

REFERENCES:
patent: 4959314 (1990-09-01), Mark et al.
Rotundo (1988), J. Biol. Chem. 263(36):19398-19406.
Soreq et al., (Dec. 1990), Proc. Natl. Acad. Sci. U.S.A., vol. 87, pp. 9688-9692.
Towbin et al., (Sep. 1979), Proc. Natl. Acad. Sci. U.S.A., vol. 76, pp. 4350-4354.
Velan, B. et al., Cellular and Molecular Neurobiology 11, 143-156 (1991).

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